Endocrine Abstracts

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause (<2 percent) of endogenous Cushing’s syndrome, usually characterized by enlarged adrenal glands containing multiple functioning nonpigmented macronodules. PBMAH was thought to be sporadic, but recently a genetic component has been described. Specifically, inactivating mutations in ARMC5 (Armadillo-repeat containing 5), a suppressor gene, have been found in many familial c...

Background: Preconception planning is essential for a successful pregnancy in women with pregestational diabetes,although many women still do not plan their pregnancies. The rapid outbreak of T2DM among the general population, including women of childbearing age, is one of the largest public health issues. The aim of this study is to describe time trends in preconception planning, obstetric and perinatal outcomesduring the past 8 years in ourpregestational care unit, focusing ...

Introduction: Stiff person syndrome (SPS) is a rare neurological disease resulting in stiffness and spasm of muscles and, as a consequence, severely impaired ambulation. Pathophysiology of the disease is based on an increased muscle activity caused by the decreased level of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) due to an autoimmune attack against glutamic acid decarboxylase (GAD); enzyme which is also one of the main autoantigens of type 1 diabetes mel...

Introduction: Endonasal endoscopic transsphenoidal surgery (EETS) for a sellar or suprasellar mass poses potential complications, including transient or permanent hypopituitarism. Adrenocortical insufficiency is especially worrisome given its potentially life-threatening course, if untreated. Usual clinical practice includes administration of perioperative “stress doses” of steroids followed by long term steroid replacement until the hypothalamic-pituitary-adrenal ax...

Introduction: 46,XX testicular disorder of sex development (DSD) is a rare syndrome, which is characterized by a female karyotype in discordance with a male phenotype. It is presented with primary hypogonadism, gynecomastia and infertility. About 80–90% of 46,XX testicular DSD cases are positive for SRY gene. Appearance of external genitalia and masculinization are usually normal in 46,XX SRY-positive casesClinical case: A 41-year-old male came with...

In the healthy liver, GH signals through multiple pathways to modulate hepatic function, with JAK2/STAT5b required to maintain circulating IGF1 levels. It has been previously reported that mice with developmental knockout of hepatocyte GHR, JAK2 or STAT5 develop steatosis associated with glucose intolerance, systemic insulin resistance and white adipose tissue (WAT) lipolysis. These changes are thought to be secondary to increased circulating GH, due to loss of IGF1 negative f...

ContextThe effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with Euthyroid-Sick-Syndrome-ESS, thyrotoxicosis or suppression of thyroid-function-tests (TFTs) reported which can lead to inadequate diagnoses and treatments.ObjectiveThe aim of this case report is to describe, for the first time, a possible interference of macro-TSH in a patient with SARS-CoV2 and thy...

Aim: The use of continuous subcutaneous insulin infusion (CSII) systems in type 1 diabetic patients (DM1) is progressively increasing, leading to an increase in cases in which its maintenance during hospitalization is considered. The objective of the study is to analyze the safety of glycemic control with CSII therapy during hospitalization in DM1 adults.Material and Methods: Retrospective observational study on a cohort of DM1 people hospitalized the la...

Introduction: Immune checkpoint inhibitors (ICIs) are a type of immunotherapy approved for the treatment of certain tumors. As the use of ICIs increases, the incidence of rare side effects, called immune-related adverse effects (IRAE), is also increasing, and can affect different systems (gastrointestinal, hepatic, and endocrine among others), with hyponatremia being a possible side effect in patients treated with ICIs. Our objective is to describe one of the few clinical case...

Background: Although the majority of cases of hyperandrogenism in postmenopausal women are due to functional causes, the sudden appearance of a severe and rapidly progressive condition, especially if associated with signs of virilization and defeminization, requires always ruling out the existence of an androgen-producing tumor at both the adrenal and ovarian levels. Etiological diagnosis can be difficult because ovarian tumors are not easily demonstrable by imaging.<p cla...